https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:4358 90% (p=.14), the duration of gametocyte carriage increased from 3 to 22 weeks (per 1000 person‐weeks) between 1998 and 2002 (p≺.001). The dhfr and dhps mutations associated with sulfadoxine‐pyrimethamine resistance were the most important drivers of the increased gametocytemia, although these mutations were not associated with increased pretreatment asexual parasite density or slower asexual parasite clearance times. The geometric mean gametocyte duration and area under the gametocyte density time curve (per 1000 person‐weeks) were 7.0 weeks and 60.8 gametocytes/μL per week, respectively, among patients with wild‐type parasites, compared with 45.4 weeks (p=.016) and 1212 gametocytes/μL per week (p=.014), respectively, among those with parasites containing 1–5 dhfr/dhps mutations. Conclusions: An increased duration and density of gametocyte carriage after sulfadoxine-pyrimethamine treatment was an early indicator of drug resistance. This increased gametocytemia among patients who have primary infections with drug‐resistant Plasmodium falciparum fuels the spread of resistance even before treatment failure rates increase significantly.]]> Wed 11 Apr 2018 13:43:20 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:4974 Sat 24 Mar 2018 07:46:55 AEDT ]]>